Fresh analysis suggests that people who stop using popular weight-loss injections like Wegovy and Mounjaro may regain shed pounds far faster than those who halt conventional diet and exercise plans.
Research printed in a leading health publication shows that while overweight people frequently drop about a fifth of their body weight while on the medication, the mass is regained at an estimated rate of nearly a kilo each month once they quit.
"Users purchasing these medications must be informed of the danger of fast weight regain when the treatment ends," stated researcher Dr. Susan Jebb.
That rate of recovery implies a reversion to original weight within about 18 months.
Comparing Approaches
The research, which reviewed 37 of studies involving thousands of participants, contrasted the effects of the injectable medications with conventional dieting.
Researchers emphasize that individuals who shed pounds through lifestyle changes alone typically experience a slower creep back—around 100 grams monthly—post-intervention.
Explaining the Rapid Rebound
Doctors believe the way of the injections explains the accelerated regain.
GLP-1 drugs imitate a body's own chemical called GLP-1, which controls hunger.
"Artificially providing GLP-1 concentrations far above than normal may cause the body to produce less of its endogenous hormone, and may also diminish responsiveness to its actions," said Dr. Adam Collins, a nutrition expert.
"Stopping of this GLP-1 'fix' results in appetite is uncontrolled, making excessive eating a significant risk."
A Chronic Disease?
Health authorities recommend the injections for individuals with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Professionals contend that, due to the likelihood of relapse, the treatment should be considered life-long.
This opinion is reinforced by pharmaceutical companies, who state that the findings "emphasize the persistent nature of excess weight," similar to managing conditions like diabetes.
Patient Accounts
People who have come off the medication report a intense resurgence of appetite.
"I experienced something that goes on and you become ravenous," said a patient.
The struggle is compounded if patients have not developed permanent lifestyle or habit changes during treatment.
Significant Adoption
Survey data show that a significant number of people in the UK have tried weight-loss jabs in the past year, with interest continuing to grow.
- Use is higher among women than males.
- The middle-aged age group shows the greatest level of interest.
- Many obtain the medications through private healthcare rather than the NHS.
Finally, experts emphasize that while these medications are powerful agents for weight loss, they are not a standalone fix and maintained weight loss relies on ongoing lifestyle changes.
